Dilutional Exchange in Neonates

Baby information

Baby's gestation:
Baby's weight: grams
Baby's haematocrit:   %    


This page and calculator is based upon Great Ormond Street's Clinical Guidelines for neonatal polycythaemia1 which can be found here.

Neonatal polycythaemia may present as jitteriness, hypoglycaemia or apnoea, or can be asymptomatic. This occurs more often in infants with placental insufficiency, infants of diabetic mothers, twin-twin transfusion and those with trisomy 13, 18 or 21.

Aims of dilutional exchange: to reduce haematocrit (or packed cell volume - PCV) to 55%. This aims to prevent hyperviscosity, which may be associated with sludging in small vessels, thrombosis or bleeding.


Is dilutional exchange recommended here?
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Volume to be exchanged

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Central lines ?

Umbilical Venous Catheter (UVC)

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Length: Awaiting info

Umbilical Arterial Catheter (UAC)

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Length: Awaiting info


  1. Exchange transfusion protocol, Great Ormond Street Hospital, London, 26 October 2011 - [Link]
  2. Fletcher MA, MacDonald MG, Avery GB. Atlas of procedures in Neonatology. JB Lippincott Co, Philadelphia 1983 - View on Amazon